Senior Scientist Crystallization
Company: Sanofi EU
Location: Cambridge
Posted on: May 15, 2025
Job Description:
Job title: Senior Scientist CrystallizationLocation: Cambridge,
MA -About the JobAre you ready to shape the future of medicine? The
race is on to speed up drug discovery and development to find
answers for patients and their families. Your skills could be
critical in helping our teams accelerate progress.We are looking
for a highly motivated individual with a mindset to implement
changes. She/He will be recognized as technical expert in the field
of crystallization and solid-state chemistry. The successful
candidate will work in a cutting-edge scientific global
crystallization department in Sanofi's R&D CMC Synthetic
organization. - The job is in Cambridge MA, but close collaboration
with colleagues in France is required. - Crystallization Scientists
work cross functionally to select active pharmaceutical ingredients
(API) solid forms for development and deliver robust commercial API
crystallization processes. - Process development may be directed to
either batch or continuous processes. - Collaborative work with
Chemists and Engineers on complex drug substance intermediate
crystallizations will also be required. - Work starts at candidate
selection and continues to commercial launch. - We strongly believe
that innovation in process development, data science and modelling
will be key drivers to transform Pharma process development. -We
are an innovative global healthcare company with one purpose: to
chase the miracles of science to improve people's lives. We're also
a company where you can flourish and grow your career, with
countless opportunities to explore, make connections with people,
and stretch the limits of what you thought was possible. Ready to
get started?Main Responsibilities: -
- Work with internal partners in Drug Product development,
Biopharmaceutics and Analytical to select the API physical form for
new NCEs. - This includes assessment of the manufacturability (API
solid form space complexity, physical properties, scalability,
stability) -
- Development of processes to consistently produce API with the
required quality attributes using both batch and continuous
platforms. - Expectations include; -
- Team Interactions - Integrate closely with project team members
such as Chemists, Analysts, Formulators and Engineers/Modelers to
develop API processes that are closely coordinated with API route
selection and Drug Product development. - - -
- Digital Development - Apply AI/Modeling to transform
development from traditional data driven statistical approaches to
more efficient and effective Digital Development. -
- Domain knowledge - Use a strong background in Crystallization
Engineering and/or Solid-State Chemistry to understand and apply
strategies to control API physiochemical properties such as
particle size distribution, impurities concentration and crystal
form. -
- Experimentation - Apply strong lab skills to deliver well
designed efficient experimental plans required for process
development across a wide range of crystallization, isolation and
size reduction process equipment. - - -
- Analytical - Perform physiochemical analysis to understand
process and characterize products this includes but is not limited
to XRD, DSC, PSD, SEM, optical microscopy, LC, GC, KF.---
- The candidate will be expected to dedicate part of their time
to work on continuous improvement with internal resource or through
academic collaboration. - Some potential areas for improvement
include; -
- Development of models to understand and describe the rejection
of impurities in intermediate and API crystallizations. - - -
- Develop crystallization models (Digital Twins) for batch and
continuous process and use Global System Analysis tools (e.g.
gPROMS) to identify CPPs, Design Space and Control Strategies. -
- Identify and test Particle Engineering approaches to improve
API physical properties such as supersaturation control, seed
conditioning and agglomeration. -
- Author publications, patents and present in technical
conferences. -
- Lead Tech Transfer of crystallization to the Pilot Plant and
Manufacturing. - This includes support for technical and HSE risk
assessments, review of Master Batch Records and campaign coverage
for key batches. -
- Provide concise technical presentations to communicate work to
project teams, cross functional teams and management. - Document
all work on projects and continuous improvements in eLNB
experiments and summarize in Technical Reports. - - -
- Establish/extend external network by providing leadership on
academic, industrial, or government sponsored collaborations. -
Steer collaboration projects to address gaps in scientific
knowledge. - - - -About YouBasic Qualifications: -
- PhD in Chemical engineering, Solid State Chemistry or related
field or a master's degree with a minimum of 4 years of experience.
-
- Proven track record in crystallization development. -
- An ability to work as part of a team, engaging other scientists
with complementary skill sets in the field of pharmaceutical
development. -
- A change agent mentality, proposing novel approach to
challenging scientific questions and exploring new modeling
approaches. -
- Ability to design and deliver lab experimental plans for
crystallization process development including use of typical
process and analytical experiment. -Preferred Qualifications: -
- Familiar with PAT and common off-line analytical technics such
as HPLC, GC and NMR -
- Modeling experience using gPROMS, DynoChem, Matlab, Python or
similar programming languages. -
- Some knowledge in Multivariate Analysis, chemometrics and
statistics -
- Experience in the development and scale-up of continuous
processes -Domestic and international travel may be required
(5-10%). -Why Choose Us?
- Bring the miracles of science to life alongside a supportive,
future-focused team.------
- Discover endless opportunities to grow your talent and drive
your career, whether it's through a promotion or lateral move, at
home or internationally.------
- Enjoy a thoughtful, well-crafted rewards package that
recognizes your contribution and amplifies your impact.------
- Take good care of yourself and your family, with a wide range
of health and wellbeing benefits including high-quality healthcare,
prevention and -wellness programs and at least 14 weeks'
gender-neutral parental leave.Sanofi Inc. and its U.S. affiliates
are Equal Opportunity and Affirmative Action employers committed to
a culturally diverse workforce. All qualified applicants will
receive consideration for employment without regard to race; color;
creed; religion; national origin; age; ancestry; nationality;
marital, domestic partnership or civil union status; sex, gender,
gender identity or expression; affectional or sexual orientation;
disability; veteran or military status or liability for military
status; domestic violence victim status; atypical cellular or blood
trait; genetic information (including the refusal to submit to
genetic testing) or any other characteristic protected by
law.#GD-SA ---#LI-SA#LI-Onsite -#vhd -All compensation will be
determined commensurate with demonstrated experience. Employees may
be eligible to participate in Company employee benefit programs,
and additional benefits information can
Keywords: Sanofi EU, West Hartford , Senior Scientist Crystallization, Other , Cambridge, Connecticut
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